New Sheffield research could help to develop preventative treatments for heart disease

Source: British Heart Foundation

Follow this link for full text

Date of publication: March 2019

Publication type: Research

In a nutshell: Researchers at the University of Sheffield are to study if ‘turning off’ a protein could help prevent heart attacks and strokes. Previous research found that a protein, known as c-Rel, is ‘switched on’ by damage to the blood vessel walls, and accelerates the build-up of fatty plaques even further. In this study, Professor Evans will investigate how removing c-Rel affects the progression of the disease in mice. If mice that have had c-Rel ‘switched off’ or removed are shown to have lower levels of build-up of these dangerous plaques, it could pave the way for developing drugs to block this protein and reduce a person’s risk of heart attack and stroke.

Length of publication: 1 webpage

Some important notes: Please contact your local NHS library if you cannot access the full text. Follow this link to find your local NHS library.

Acknowledgement: British Heart Foundation

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