New cholesterol-lowering drug shows promise

May 14, 2019

Source: NHS News – Behind the Headlines

Follow this link for full text

Date of publication: March 2019

Publication type: News item

In a nutshell: A study has looked into the safety of a new treatment to lower low-density lipoprotein (LDL), commonly known as “bad” cholesterol.

High cholesterol can increase the risk of cardiovascular disease, which kills about 150,000 people in the UK each year.

Researchers recruited over 2,000 people who were already taking statins to lower their cholesterol. They were split into 2 groups. One group was given the new drug, bempedoic acid, alongside their statin for 1 year. The other group was given a dummy drug (placebo).

After 3 months, those who took bempedoic acid had lowered their bad cholesterol by around 17% compared to those on the placebo. There was no difference in reported side effects between this drug and the placebo over the course of 1 year. The dropout rate because of side effects was slightly higher in the bempedoic acid group (11%) compared with the placebo group (7%).

This study adds to the research looking for new cholesterol-lowering treatments when statins either don’t work or cause undesirable side effects. However, bempedoic acid is not currently a licensed treatment. The safety of the drug needs to be confirmed before it is made available.

Length of publication: 1 webpage

Some important notes: Please contact your local NHS library if you cannot access the full text. Follow this link to find your local NHS library.

Acknowledgement:   NHS News – Behind the Headlines     

 

Advertisements

Smartphone ECG could be used in A&E to detect serious heart conditions

May 14, 2019

Source: British Heart Foundation

Follow this link for full text

Date of publication: March 2019

Publication type: News item

In a nutshell: A smartphone-based ECG recorder is five times more effective at diagnosing heart rhythm problems than standard tests, according to new research. Researchers at the University of Edinburgh and NHS Lothian carried out the first randomised control trial of the device, the AliveCor® KardiaMobile, in 243 people presenting with heart palpations or near blackout at 15 Emergency Departments across the UK. The device enabled doctors to diagnose the cause of the palpitations in over 40 per cent more patients than standard tests alone.

Length of publication: 1 webpage

Some important notes: Please contact your local NHS library if you cannot access the full text. Follow this link to find your local NHS library.

Acknowledgement: British Heart Foundation


Potential new heart attack treatment

May 14, 2019

Source: British Heart Foundation

Follow this link for full text

Date of publication: March 2019

Publication type: Research

In a nutshell: Scientists have found a potential new drug for treating the heart damage caused by a heart attack by targeting the way the heart reacts to stress. The research team, led by BHF Professor Michael Schneider at the National Heart and Lung Institute, Imperial College London, used stem cells to grow heart tissue and mimic a ‘heart attack in a dish’, and were able to block the chemical signals within heart muscle that lead to cell death and heart damage.

Length of publication: 1 webpage

Some important notes: Please contact your local NHS library if you cannot access the full text. Follow this link to find your local NHS library.

Acknowledgement: British Heart Foundation


Eggs linked to heart disease and death, study suggests

May 14, 2019

Source: British Heart Foundation

Follow this link for full text

Date of publication: March 2019

Publication type: Research

In a nutshell: High levels of dietary cholesterol, like those found in eggs, are linked to an increased risk of heart and circulatory disease, or even death, according to a new study published in JAMA.

Length of publication: 1 webpage

Some important notes: Please contact your local NHS library if you cannot access the full text. Follow this link to find your local NHS library.

Acknowledgement: British Heart Foundation


New Sheffield research could help to develop preventative treatments for heart disease

May 14, 2019

Source: British Heart Foundation

Follow this link for full text

Date of publication: March 2019

Publication type: Research

In a nutshell: Researchers at the University of Sheffield are to study if ‘turning off’ a protein could help prevent heart attacks and strokes. Previous research found that a protein, known as c-Rel, is ‘switched on’ by damage to the blood vessel walls, and accelerates the build-up of fatty plaques even further. In this study, Professor Evans will investigate how removing c-Rel affects the progression of the disease in mice. If mice that have had c-Rel ‘switched off’ or removed are shown to have lower levels of build-up of these dangerous plaques, it could pave the way for developing drugs to block this protein and reduce a person’s risk of heart attack and stroke.

Length of publication: 1 webpage

Some important notes: Please contact your local NHS library if you cannot access the full text. Follow this link to find your local NHS library.

Acknowledgement: British Heart Foundation


E-cigarettes linked to heart attacks, coronary artery disease and depression

May 14, 2019

Source: Science Daily

Follow this link for full text

Date of publication: March 2019

Publication type: News item

In a nutshell: New research shows that adults who report puffing e-cigarettes, or vaping, are significantly more likely to have a heart attack, coronary artery disease and depression compared with those who don’t use them or any tobacco products.

Length of publication: 1 webpage

Some important notes: Please contact your local NHS library if you cannot access the full text. Follow this link to find your local NHS library.

Acknowledgement:   Science Daily