Deadly inherited condition more common than type 1 diabetes in children

March 17, 2017

Source: British Heart Foundation

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Date of publication: February 2017

Publication type: Research

In a nutshell: Approximately one in every 250 people in the UK has familial hypercholesterolaemia (FH), a potentially deadly inherited condition which, if undiagnosed, can cause people to die from a heart attack at an early age.

Our figures suggest that FH affects around 250,000 people and is more common than type one diabetes in children, which affects around one in 500 children.

FH causes abnormally high levels of cholesterol in a person’s blood, meaning that otherwise healthy individuals are at a much greater risk of having a heart attack at a young age. Without treatment, people with FH can die prematurely in their 20s, 30s or 40s. Each child of a parent who has FH has a 50 per cent chance of inheriting the condition.

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Some important notes: Please contact your local NHS library if you cannot access the full text. Follow this link to find your local NHS library.

Acknowledgement: British Heart Foundation

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Genetic link to dangerous aneurysms could aid future treatment

December 9, 2016

Source: British Heart Foundation

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Date of publication: November 2016

Publication type: News item

In a nutshell: Thousands of lives could be saved every year after it was discovered a fatal cardiovascular condition could be linked to four genes, according to Leicester research we helped fund.

A 10-year project, led by Professor Matt Bown, looked at 10,000 people worldwide and found those who had suffered an abdominal aortic aneurysm (AAA) had four genes in common.

It is hoped that the findings, published in the journal Circulation Research, could help doctors understand more about the condition, which can lead to fatal internal bleeding if left untreated.

Length of publication: 1 webpage

Some important notes: Please contact your local NHS library if you cannot access the full text. Follow this link to find your local NHS library.

Acknowledgement: British Heart Foundation


NHS failing to screen for deadly heart condition

February 10, 2011

Source: National Institute for Health and Clinical Excellence

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Date of publication: January 2011

Publication type: Press release

In a nutshell: 100.000 people are at risk of developing familial hypercholesterolaemia (FH) as trusts fail to act on NICE guidelines which call for early diagnosis. A UK-wide audit found that very few families were systematically genetically screened for the inherited condition.

Length of publication: 1 webpage

Some important notes: Please contact your local NHS library if you cannot access the full text. Follow this link to find your local NHS library.