Antibodies cut heart attack risk

October 19, 2018

Source: British Heart Foundation

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Date of publication: September 2018

Publication type: Research

In a nutshell: Specific antibodies could protect against heart attacks, according to a study published in the journal EBioMedicine. Researchers from Imperial College London studied patients with high blood pressure of whom 87 had developed coronary heart disease (CHD) in one study in collaboration with Lund University in Sweden. They also studied another 143 patients who had their heart arteries extensively studied using cutting edge techniques in collaboration with researchers from the Thorax centre in Holland.

They found that those who had heart attacks in the first study, as well as those whose arteries had unstable fatty plaques in the second study had much lower levels of an antibody called IgM anti MDA-LDL. Those who had the highest levels, were well protected from developing dangerous plaques in their arteries, with around a 70 per cent less chance of developing heart disease over nearly five years from one of the studies.

Length of publication: 1 webpage

Some important notes: Please contact your local NHS library if you cannot access the full text. Follow this link to find your local NHS library.

Acknowledgement:   British Heart Foundation

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Antibodies cut heart attack risk

September 21, 2018

Source: British Heart Foundation

Follow this link for full text

Date of publication: September 2018

Publication type: Research

In a nutshell: Researchers from Imperial College London studied patients with high blood pressure of whom 87 had developed coronary heart disease (CHD) in one study in collaboration with Lund University in Sweden. They also studied another 143 patients who had their heart arteries extensively studied using cutting edge techniques in collaboration with researchers from the Thorax centre in Holland.

They found that those who had heart attacks in the first study, as well as those whose arteries had unstable fatty plaques in the second study had much lower levels of an antibody called IgM anti MDA-LDL. Those who had the highest levels, were well protected from developing dangerous plaques in their arteries, with around a 70 per cent less chance of developing heart disease over nearly five years from one of the studies.

Length of publication: 1 webpage

Some important notes: Please contact your local NHS library if you cannot access the full text. Follow this link to find your local NHS library.

Acknowledgement: British Heart Foundation


Diabetes drug could help millions with heart and circulatory disease

June 15, 2018

Source: British Heart Foundation

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Date of publication: June 2018

Publication type: Research

In a nutshell: New research has found that metformin – a cheap drug routinely used for the treatment of type 2 diabetes – could help millions of people living with heart and circulatory disease in the UK.

Two studies involving the drug, led by Dr Ify Mordi and colleagues at the University of Dundee, at the University of Dundee and presented today at the British Cardiovascular Society (BCS) Conference in Manchester, have provided promising results for patients with high blood pressure-induced heart damage and a condition called aortic stenosis, which causes heart failure.

The BHF-funded MET-REMODEL trial, found that metformin could reverse harmful thickening of the left ventricle – the heart’s main pumping chamber. It also helped to bring down high blood pressure and reduce body weight in patients who had a heart attack.

Length of publication: 1 webpage

Some important notes: Please contact your local NHS library if you cannot access the full text. Follow this link to find your local NHS library.

Acknowledgement: British Heart Foundation


Embrace Mediterranean or Nordic diets to cut disease, WHO says

June 15, 2018

Source: The Guardian

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Date of publication: May 2018

Publication type: News item

In a nutshell: Britain could lower its rates of cancer, diabetes and cardiovascular disease by embracing Mediterranean- or Nordic-style diets, a major study into the benefits of healthy eating suggests.

A review by the World Health Organization found compelling evidence that both diets reduce the risk of the common diseases, but noted that only 15 out of 53 countries in its European region had measures in place to promote the diets.

Length of publication: 1 webpage

Some important notes: Please contact your local NHS library if you cannot access the full text. Follow this link to find your local NHS library.

Acknowledgement: The Guardian


Research highlights the urgent need for better diagnosis of deadly inherited heart conditions

June 15, 2018

Source: British Heart Foundation

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Date of publication: March 2018

Publication type: News item

In a nutshell: New figures we’ve released today show that people with potentially deadly inherited heart conditions are too often not diagnosed until a life-threatening cardiac arrest or sudden death in the family. Our survey of almost 200 people with inherited heart conditions from across the UK found that one in six (16%) people with a deadly inherited heart condition are only diagnosed after having a cardiac arrest, whilst a fifth (18%) of people are diagnosed after a sudden death in the family.

Length of publication: 1 webpage

Some important notes: Please contact your local NHS library if you cannot access the full text. Follow this link to find your local NHS library.

Acknowledgement: British Heart Foundation


Tests can give families of SADS victims a lifesaving diagnosis

June 15, 2018

Source: British Heart Foundation

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Date of publication: March 2018

Publication type: Research

In a nutshell: A study published in the Journal of American College of Cardiology suggests a series of investigative tests should be carried out on the loved ones of SADS victims, to try and diagnose an underlying hidden heart condition and protect them from another tragedy.

The series of tests include an ECG, echocardiogram, exercise test and the ajmaline provocation test – a procedure used to reveal abnormal electrical activity in the heart.

The researchers, based at St George’s University of London, evaluated over 300 families who had lost a relative to SADS over a 10-year period. The team looked at 911 relatives in total and 22% of them were diagnosed with an inherited cardiac condition. The most common condition found in families was Brugada syndrome, affecting 16% of all relatives.

Brugada syndrome is a rare inherited heart rhythm disturbance that restricts the flow of sodium ions into the heart cells. If diagnosed, people with Brugada syndrome can be treated with medications or fitted with an ICD, to shock the heart back into rhythm if it stops.

Length of publication: 1 webpage

Some important notes: Please contact your local NHS library if you cannot access the full text. Follow this link to find your local NHS library.

Acknowledgement: British Heart Foundation


Seven ways … to lower your heart age

February 22, 2018

Source: The Guardian

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Date of publication: January 2018

Publication type: News item

In a nutshell: Article about how you can lower your risk of heart attack or stroke, at any age.

Length of publication: 1 webpage

Some important notes: Please contact your local NHS library if you cannot access the full text. Follow this link to find your local NHS library.

Acknowledgement: The Guardian